5_Viral DNA Replication

Lehninger Principles of Biochemistry

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Viral DNA Replication and Antiviral  Therapies Sourav Mukherjee, PhD
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 Herpes Virus replication    Antiviral therapies – HSV-1 DNA Polymerase  (DNA pol)  inhibitors  Human Immunodeficiency Virus (HIV) replication   Antiviral therapies – HIV-1 Reverse Transcriptase (RT)                  inhibitors    Hepatitis C Virus (HCV) replication  Antiviral therapies – NS5b inhibitors in clinical trials
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Herpes Virus Replication  Large family comprising of dsDNA viruses including HCV,  EBV, CMV, VZV etc.  125-250 kb genomes. Contains direct and inverse repeats,  Approx. 80 ORFs  Origin-binding protein, DNA pol, Helicase/primase, SSBP – 4  major proteins  dsDNA – dsDNA - ssRNA - Protein
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HSV-1 DNA Polymerase  Key component of HSV-1 replication  UL42 (Processivity) subunits  Binds to ssDNA, has high fidelity and mismatch repair  mechanisms  Incorporates dNTPs in a template-dependent fashion
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HSV DNA Replicati : Video on HSV DNA Replication
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Antiviral therapies – HSV-1 DNA  polymerase inhibitors  2 major classes – Nucleoside/Nucleotide analogs and Non-  Nucleoside/Nucleotide analogs   Nucleoside/Nucleotide analogs comprised of 2 subclasses –  Nucleoside and Nucleotide analogs  Non- Nucleoside/Nucleotide analogs comprised of many 
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5_Viral DNA Replication - ViralDNAReplicationandAntiviral...

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