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8_Repair

Lehninger Principles of Biochemistry

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Lecture 8: DNA Damage & Repair Chemical reactions and some physical processes constantly damage genomic DNA At the molecular level, damage usually involves changes in the structure of one of the strands Vast majority are corrected by repair systems using the other strand as a template Some base changes escape repair and the incorrect base serves as a template in replication The daughter DNA carries a changed sequence in both strands; the DNA has been mutated Accumulation of mutations in eukaryotic cells is strongly correlated with cancer; most carcinogens are also mutagens
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Types of DNA Repair Systems Mismatches arise from occasional incorporation of incorrect nucleotides Abnormal bases arise from spontaneous deamination reactions or via chemical alkylation Pyrimidine dimers form when DNA is exposed to UV light Backbone lesions occur from exposure to ionizing radiation
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Reading 8| pp. 289-292 25 | pp. 993-1016 © 2009 W. H. Freeman and Company
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