11_Genetic Code

Lehninger Principles of Biochemistry

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Lecture 11 The genetic Code The genetic code Translation: RNA-dependent protein synthesis Protein Metabolism (3 Lectures) :
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Reading 27 | pp. 1065-1074 © 2009 W. H. Freeman and Company
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Protein Synthesis is a Very Complex Process Occurs in a large macromolecular assembly called the ribosome , which is made of many proteins and several RNA molecules into a functional ribosome Uses a large number of tRNAs that interact with mRNA Each tRNA is charged with one of the 20 common amino acids by 20 different aminoacyl tRNA synthetases Requires a dozen or more additional protein factors for initiation, elongation, and termination of translation Involves perhaps 100 additional enzymes that carry out a variety of modifications with many proteins
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Protein Synthesis Occurs on Ribosomes In eukaryotes, most ribosomes are attached to the cytosolic face of endoplasmic reticulum
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Crick’s Adaptor Hypothesis It was recognized in early 1950s
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11_Genetic Code - Lecture 11 The genetic Code Protein...

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