13_Targeting

Lehninger Principles of Biochemistry

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Lecture 13 Protein Targeting Signal Sequences Post-translational modifications The proteasome Key topics :
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Lecture Connections 27 | Protein Metabolism © 2009 W. H. Freeman and Company
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Amino terminal Signal sequences
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Directing proteins to the endoplasmic reticulum
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Glycoprotein synthesis
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Antibiotics block glycoprotein synthesis Mimics UDP-N-acetylglucosamine
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Unformatted text preview: Blocks Step 1 Targeting proteins to the lysosome Phosphorylation of mannose residues on lysosome-targeted enzymes Targeting of nuclear proteins Signal sequences in bacteria Model for protein export in bacteria Endocytosis pathways in eukaryotes Clathrin Ubiquitin attachment targets proteins for degradation...
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13_Targeting - Blocks Step 1 Targeting proteins to the...

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