14_Regulation 1

Lehninger Principles of Biochemistry

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1 Lecture 14 Regulation of Gene Expression 1 DNA elements that control transcription Protein factors that control transcription Lac operon as a model for regulation Regulation of protein synthesis by RNA Key topics :
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2 Reading 28 | pp. 1115-1136 © 2009 W. H. Freeman and Company
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3 How to Control Protein’s Activity in The Cell? How much primary RNA transcript to make? How to process this RNA into mRNA? How rapidly to degrade the mRNA? How much protein to make from this mRNA? How efficiently to target the protein to its location? How to alter the intrinsic activity of this protein? How rapidly to degrade the protein?
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4 Processes that Affect Protein’s Concentration and Activity
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5 DNA Sequences Involved in Regulation of Gene Expression Most bacterial promoters include the conserved –10 and –35 regions that interact with the σ factor of RNA polymerase Some promoters also include the upstream element that interacts with the α subunit of RNA polymerase
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11 Two Main Mechanisms to Regulate Transcription in Bacteria Use of different σ factors These recognize different classes of promoters Allows coordinated expression of different sets of genes Binding other proteins ( transcription factors
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14_Regulation 1 - Lecture 14 Regulation of Gene Expression...

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