15_Regulation 2

Lehninger Principles of Biochemistry

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1 Lecture 15 Regulation of Gene Expression 2 DNA elements that control transcription Protein factors that control transcription Lac operon as a model for regulation Regulation of protein synthesis by RNA Key topics :
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2 Reading 28 | pp. 1115-1136 © 2009 W. H. Freeman and Company
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3 Regulation of Transcription in Eukaryotes General transcription factors TATA box binding protein (TBP) Transcription factors for the assembly of the initiation complex Promoter proximal / distal enhancer binding factors Homeodomain proteins share similarities with helix-turn-helix bacterial counterparts nut often involve water bridges between DNA and protein Leucine zippers are made of two amphipathic polypeptides. One side of each peptide is hydrophobic, facilitating dimerization Zinc fingers form elongated loops held together by a single Zn
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Unformatted text preview: ++ ion 4 Homeodomain Proteins • Notice that an α-helix interacts with DNA via the major groove 5 Leucine Zippers 6 Eukaryotic Promoters and Regulatory Proteins 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Chapter 28: Summary • Regulation of gene transcription is a common and efficient way to control protein’s activity in the cell • Regulation of transcription is commonly achieved via binding of inhibiting and activating proteins to the DNA near the beginning of the gene • Transcription factors frequently bind via an α helix that protrudes into the major groove of dsDNA • Binding of mRNA to ribosome is modulated by small regulatory RNA molecules In this chapter, we learned that:...
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