22_Biosignalling2

Lehninger Principles of Biochemistry

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Unformatted text preview: Lecture 22 Bio-Signaling II – Guanylyl Cyclases – Adapter Proteins – Gated Ion Channels – Hormone Receptors – Cyclins – Cancer Reading 12 | pp. 444-469 © 2009 W. H. Freeman and Company SH2-Domains Binds Proteins with Phosphotyrosine Residue Mechanism of autoinhibition of Src and GSK3 Modular Structure of Signaling Proteins Gated Ion Channels • Regulate transport of ions across cell membranes in response to – Changes in the membrane potential – Ligand binding to specific receptor sites • Many important roles in the nervous system – Voltage-gated sodium channels – Nicotinic acetylcholine receptor – Ionotropic glutamate receptor – Gamma aminobutyric acid receptor A Membranes are Electrically Polarized • The inside of the cell is typically negatively charged compared to the outside: V m –50 to –70 mV • The membrane potential is largely due to electrogenic Na + K + ATPase – 3 Na + out – 2 K + in • Flow of ionic species across the membrane depends on its concentration gradient and overall electrical potential Voltage-Gated and Ligand-Gated...
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22_Biosignalling2 - Lecture 22 Bio-Signaling II –...

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