Kuby Immunology, Sixth Edition

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CHAPTER 9: T-CELL RECEPTOR I. EARLY STUDIES OF THE T-CELL RECEPTOR A. Classic experiments demonstrated to self-MHC restriction of the T-cell receptor B. T-cell receptors were isolated by using clonotypic antibodies C. The TCR β-chain gene was cloned by use of subtractive hybridization II. αβ AND γδ T-CELL RECEPTORS III. ORGANIZATION AND REARRANGEMENT OF TCR GENES A. TCR variable-region genes rearrange in a manner similar to antibody genes B. Mechanism of TCR DNA rearrangements C. Allelic exclusion of TCR genes D. Rearranged TCR genes are assembled from V, J, and D
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Unformatted text preview: gene segments E. TCR diversity is generated like antibody diversity but without somatic mutation IV. T-CELL RECEPTOR COMPLEX: TCR-CD3 V. T-CELL ACCESSORY MEMBRANE MOLECULES A. CD4 and CD8 coreceptors bind to conserved regions of MHC class II or I molecules B. Affinity of TCR for peptide-MHC complexes is enhanced by coreceptors VI. THREE-DIMENSIONAL STRUCTURES OF TCR-PEPTIDE-MHC COMPLEXES CHAPTER 9: T-CELL RECEPTOR A. TCRs interact differently with class I and class II molecules B. alloreactivity of T cells...
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chapter9 - gene segments E TCR diversity is generated like...

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