lecture1_S2009

lecture1_S2009 - 18.417: Introduction to Computational...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
18.417: Introduction to Computational Structural Biology Introduction to RNA secondary structure prediction Jérôme Waldispühl Department of Mathematics, MIT
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
RNA world In prebiotic world, RNA thought to have filled two distinct roles: 1. an information carrying role because of RNA's ability (in principle) to self-replicate, 2. a catalytic role, because of RNA's ability to form complicated 3D shapes. Over time, DNA replaced RNA in Its first role, while proteins replaced RNA in its second role.
Background image of page 2
RNA classification Messenger RNA: • Carry genetic information, • Structure less important. Protein RNA Non-coding RNA: • Functional, • Structure is important. mRNA ribosome Protein
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cellular functions of RNA Genetic Functions: Messenger RNA Viroids Transfer RNA Enzymatic functions: Splicing (snRNA) RNA Maturation (ribonuclease P) Ribosomic RNA Guide RNA (snoRNA)
Background image of page 4
RNA structure and function RNAs have a 3D structure, This 3D structure allow complex functions, The variety of RNA structures allow the specific recognition of a wide range of ligands, Some molecules target these RNA structures (antibiotics, antimitotics, antiviruses):
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
RNA vs DNA: Chemical nature 2’-OH group attached to sugar (instead of 2’-H): more polar Substitution of thymine by uracile = suppression of group 5-CH3 Small modifications => big effects
Background image of page 6
Global conformation: RNA vs DNA: Modification of the local and global geometry 2’OH RNA favorite: DNA favorite: C2’endo C3’endo :Local conformation
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
RNA vs DNA: Consequence of the modification of the geometry Small furrow is flat Big furrow is deep
Background image of page 8
RNA vs DNA: RNA-Protein and DNA-Protein interactions are different DNA-Protein: Secondary structure elements insert in big furrow RNA-Protein interaction are more specific.
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 32

lecture1_S2009 - 18.417: Introduction to Computational...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online