lecture9_S2009

lecture9_S2009 - 18.417: Introduction to protein structure...

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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 1/38 18.417: Introduction to protein structure prediction Charles W. O’Donnell
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 2/38 “The protein folding problem” Protein pep*de chains can switch between elongated polymers and ac*ve enzymes all by themselves . [1961, won Anfnsen Nobel Prize]
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 3/38 Simplistic dogma Proteins fold into na*ve (func*onal) structures Complicated in‐vivo by chaperones, mul*ple na*ve state conforma*ons, aggrega*on
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 4/38 Why research structure prediction? Ul*mately, biologic func*on depends on protein structure “Grand challenge” o If we understood spontaneous protein folding, we’d understand a lot $$: step 1) gene*c sequencing step 2) predict structure step 3) proFt More generally, structure predic*on only 1 tool/step in protein modeling
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 5/38 7.05 Review Understanding the physical proper*es of protein structure are essen*al for structure predic*on source: wikipedia
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 6/38 Branden & Tooze “Introduc*on to Protein Structure” – 2 nd Ed., Carl Branden, John Tooze Excellent (standard) book for learning proteins structure
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 7/38 Amino Acids Elementary building blocks of proteins Miller/Urey experiment (1953) o Mix hydrogen , water , methane , ammonia o simmer for one week o life source: www.chem.duke.edu/~jds/cruise_chem/Exobiology/miller.html source: wikipedia source: wikipedia
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 8/38 pH dependency
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March 9 th , 2009 18.417 Lecture 10: Introduction to protein structure prediction 9/38 Amino acids: simple ones
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lecture9_S2009 - 18.417: Introduction to protein structure...

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