Unformatted text preview: MCB 200 Name Fall 2007 Quiz #11 Section 1. In the early stages of the cell cycle, which speciﬁc protein complexes control progression from one phase to the next? CYCVIH 'CDK 2. Which uncontrolled characteristic of cancer cells leads to tumor formation? PreliQi'c/cé'om (fyvvéh/ ”mm 3. Tumor suppressor genes assist with the activation of what pathway, in which a
cascade of proteolysis is initiated that culminates in cell suicide? ape F EC 5:5"
4. What class of genes may the expression be improperly enhanced by a gain-of-
function mutation which promotes cell proliferation? O FTCC‘ (\6‘5 r763
(’ 5-7. List three key events in the cell cycle which are monitored by checkpoints; 1. D MA QePucQ-gm
2. CQW‘éFGScme Duplicaté‘orw 3, SPEHGUE’ _ASSSQr'-1i/c_\ A geneticist has developed DNA proﬁle tests using RF LP markers for two genes that are
responsible for the majority of inherited forms of breast cancer: BRCA 1 located on
chromosome 17 and BRCA 2 located on chromosome 13. DNA has been obtained from
a family with an inherited mutation. Mary and Sarah have been diagnosed with cancer,
whereas Jane and Joyce exhibit no current symptoms. Results of the two tests are depicted below:
Chromosome 13 Chromosome 17 Mary Jane Sarah Joyce Mary Jane Sarah Joyce EKCA ‘1 8. Which of the breast cancer genes is mutated in Joyce’s family? 9. How do you know? Fiat-7 and Bank :Lmve Cancer“ and Share: COWWCN RFLP Pafﬁ’rws 1g: £175 qiiek 10. Do the results of the DNA test indicate Joyce’s risk for increased susceptibility? N o ...
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