BBlecture9S10s

BBlecture9S10s - Principles of Bacterial Genetics...

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Unformatted text preview: Principles of Bacterial Genetics (bacterial chromosomes, plasmids) 11.1: Genetic map of the Escherichia coli chromosome 11.2: Plasmids: General Principles 11.3: Types of Plasmids and Their Biological Significance mut 1 circular linkage map of the chromosome of Escherichia coli strain K-12 (Fig 11.1, 12th ed) mut 2 plasmid : an extrachromosomal genetic element that has no extracellular form; replicates independently of host chromosome plasmid genes not essential to host plasmid replication generally carried out by cell DNA polymerase plasmid-encoded genes regulate plasmid replication rate and copy number plasmids of the same incompatibility (Inc) group exclude each other but may co-exist in cell with plasmid(s) of other Inc group(s) plasmids can be cured mut 3 electron micrograph: bacterial chromosome and plasmids (Fig 11.2, 12th ed) mut 4 mut 5 genetic map of resistance plasmid R100 : mercury sulfonamide streptomyci n tetracyclin e (Fig 11.3, 12th ed) mut 6 Principles of Bacterial Genetics (mutation) 11.4: Mutations and Mutants 11.5: Molecular Basis of Mutation 11.6: Mutation Rates 11.7: Mutagenesis 11.8: Mutagenesis and Carcinogenesis: The Ames Test mut 7 microbial genetics : grew out of microbiology in 1940s-1950s...
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BBlecture9S10s - Principles of Bacterial Genetics...

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