MS FA 10 VO - Focus on Multiple Sclerosis Karen L. OBrien,...

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Focus on Multiple Sclerosis Karen L. O’Brien, RN, MSN
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Nursing Diagnoses Impaired physical mobility Fatigue Dressing/grooming self-care deficit Risk for impaired skin integrity Impaired urinary elimination pattern Sexual dysfunction Interrupted family processes
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Multiple Sclerosis: What Chronic, progressive, degenerative disorder of the central nervous system (CNS) Characterized by disseminated demyelination of nerve fibers of the brain and spinal cord
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Multiple Sclerosis: Who Disease usually affects young to middle-aged adults Onset between 15 and 50 years of age Women are affected more than men Caucasian Cold or temperate climate
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Multiple Sclerosis Etiology and Pathophysiolo gy Cause is unknown Related to infectious, immunologic, and genetic factors Multiple genes confer susceptibility to multiple sclerosis (MS) Possibility that the association between pathogenetic agents and MS is random and there is no cause-and-effect relationship
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Multiple Sclerosis Etiology and Pathophysiology Possible precipitating factors include Infection Physical injury Emotional stress Excessive fatigue Pregnancy Poor state of health
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Multiple Sclerosis Etiology and Pathophysiology Characterized by chronic inflammation, demyelination, and gliosis(scarring) in the CNS An autoimmune disease orchestrated by autoreactive T cells “Autoaggressive”
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Multiple Sclerosis Etiology and Pathophysiology Initially triggered by a virus in genetically susceptible individuals Activated T cells migrate to CNS causing blood-brain disruption Subsequent antigen-antibody reaction leads to demyelination of axons
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Multiple Sclerosis Etiology and Pathophysiology Disease process consists of Loss of myelin Disappearance of oligodendrocytes Proliferation of astrocytes Changes result in plaque formation Plaques scattered throughout the CNS
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Multiple Sclerosis Etiology and Pathophysiology Initially the myelin sheaths of the neurons in the brain and spinal cord are attacked, but the nerve fiber is not affected Patient may complain of noticeable impairment of function
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This note was uploaded on 06/20/2011 for the course NURS 344 taught by Professor Hampson during the Spring '11 term at St. Xavier.

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MS FA 10 VO - Focus on Multiple Sclerosis Karen L. OBrien,...

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