Microsoft PowerPoint - Protein PART A

Microsoft PowerPoint - Protein PART A - together r Glycine,...

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Protein: IN DETAIL 1 PART A By S. M. Rafigh 2011
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Amino Acids, Proteins, and Enzymes Primary and Secondary Structure Tertiary and Quaternary Structure Protein Hydrolysis and Denaturation 2
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Primary Structure of Proteins The particular sequence of amino acids that is the backbone of a peptide chain or protein CH 3 3 H 3 N CH CH 3 C O N H CH C O N H CH C O N H CH C O - O CH CH CH 3 CH 3 CH 2 SH CH 2 CH 2 S + Ala-Leu-Cys-Met
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Secondary Structure – Alpha Helix Three-dimensional arrangement of amino acids with the polypeptide chain in a corkscrew shape Held by H bonds between the H of –N-H group and the –O of C=O of the fourth amino acid along the chain Looks like a coiled “telephone cord” 4
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Secondary Structure – Beta Pleated Sheet Polypeptide chains are arranged side by side Hydrogen bonds form between chains R groups of extend above and below the sheet Typical of fibrous proteins such as silk 5
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Secondary Structure – Triple Helix r Three polypeptide chains woven
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Unformatted text preview: together r Glycine, proline, hydroxy proline d hydroxylysine and hydroxylysine r H bonding between –OH groups gives a strong structure r Typical of collagen, connective tissue, skin, tendons, and cartilage 6 Tertiary Structure • Specific overall shape of a protein • Cross links between R groups of amino acids in chain isulfide disulfide –S–S– + ionic –COO – H 3 N– H bonds C=O HO– hydrophobic –CH 3 H 3 C– 7 Globular and Fibrous Proteins Globular proteins Fibrous proteins “spherical” shape long, thin fibers Insulin Hair emoglobin ool Hemoglobin Wool Enzymes Skin Antibodies Nails 8 Quaternary Structure • Proteins with two or more chains • Example is hemoglobin Carries oxygen in blood ur polypeptide chains Four polypeptide chains Each chain has a heme group to bind oxygen 9...
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Microsoft PowerPoint - Protein PART A - together r Glycine,...

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