Microsoft PowerPoint - INTRODUCTION TO Structure OF Protein - PART B [

Microsoft PowerPoint - INTRODUCTION TO Structure OF Protein - PART B [

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Unformatted text preview: INTRODUCTION TO Structure OF Protein ART PART B By S. M. S. M. S. M. S. M. Rafigh Rafigh Rafigh Rafigh 2011 Protein Structure Classification • Determining the respective structural classes of new proteins by manual or the semi- automatic methods becomes inadequate owadays. nowadays. • Classifying a new protein through traditional structural comparison. 2 Structural Fingerprints • Use data mining techniques to generate the structural fingerprints for the various structural classes. fingerprint is a set of concise and • A fingerprint is a set of concise and representative features that are common to all the protein structures in a given class. 3 Secondary Structure Element (SSE) • In a protein, certain portions of its AA sequence folds into specific shapes such as helices (H) and sheets (E) due to the forces of ature such as ydrogen bonds nd isulphide nature such as hydrogen bonds and disulphide bonds . 4 Topology • The arrangement of SSEs within a protein is called its topology 5 Classification Based on Fragments • Secondary structure classes are too restrictive to describe protein structures. How many local structure categories are necessary and sufficient?...
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This note was uploaded on 06/21/2011 for the course CHE 774 taught by Professor Prof.rafigh during the Spring '11 term at Sharif University of Technology.

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Microsoft PowerPoint - INTRODUCTION TO Structure OF Protein - PART B [

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