ch369_sp11_class_7_notes

ch369_sp11_class_7_notes - Our T.A. is Cassidy Terrell....

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Our T.A. is Cassidy Terrell. Office hours: Tuesday 11-noon in Welch 5.278
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in Chapter 5 (chapter 4 in 1st edition). Examples of protein structure and function. Myoglobin and hemoglobin are O 2 binding proteins. Myoglobin is abundant inside muscle cells. Hemoglobin is found in red blood cells.
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Myoglobin has an iron-containing “ prosthetic group ” called a “ heme ”. The heme group can reversibly bind oxygen O 2 . Myoglobin ribbon diagram (wikipedia). heme Myoglobin was the first protein to have its structure determined (1958). Max Perutz & John Kendrew received Nobel prize in 1962.
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The heme group binds in a hydrophobic pocket in the protein core. Not covalently bound. Bound by hydrophobic interactions. The heme group in myoglobin.
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The iron (Fe 2+ ) gives the heme a red color. Fe 2+ can bind 6 ligands (“octohedral coordination”). 4 ligands are contributed by the porphoryrin ring, one ligand from a histidine, leaving one space available for binding O 2 . O 2 heme
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All animals need a constant supply of O 2 . What happens to most of the O 2 that we consume? A) The O 2 we breath ends up as the oxygen in our proteins. B) The O 2 we breath is converted to H 2 O in our cells. C) The O 2 we breath is eventually converted to CO 2 in our cells. Clicker question:
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Myoglobin was the first protein to have its structure determined, it is one of the most well studied proteins in biology. Mice have recently been genetically modified to lack myoglobin. Surprisingly, they appear to be pretty healthy and are fertile. Reference: Mammen et al., Heart and Circ. Physiol., 285, H2132 (2003). Perhaps myoglobin has other functions for O 2 storage in muscle tissue, or binding oxygen free radicals (O 2 - )? Although it is clear that myoglobin binds O 2 , its full physiological function may not be fully understood.
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Fraction of myoglobin molecules with O 2 bound. This binding curve has a
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This note was uploaded on 06/20/2011 for the course CHEM 369 taught by Professor Hoffman during the Spring '11 term at University of Texas.

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ch369_sp11_class_7_notes - Our T.A. is Cassidy Terrell....

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