3_sp11_glycol_notes - Can you identify these molecules ?...

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Can you identify these molecules ?
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Glycolysis What is glycolysis? A metabolic pathway that converts glucose to pyruvate. Overall reaction of glycolysis:
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Glycolysis is an oxidation-reduction reaction: Glucose gets oxidized to pyruvate. NAD + gets reduced to NADH.
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A cofactor to remember. NADH NAD +
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10 steps in glycolysis. Each step is catalyzed by its own enzyme. Its time to make a few comments about each step. glucose 2 pyruvate
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Step 1: glucose converted to glucose-6-phosphate by hexokinase . This step uses ATP. What ??? I thought we were supposed to make ATP !!!
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The first 5 steps in glycolysis are sometimes called “preparatory phase” or “energy investment phase”. Our text uses “ energy investment phase ”. Last 5 steps in glycolysis are called “generation phase” or “energy payoff phase”. Our text uses “ energy payoff phase ”. The last 5 steps are where the ATP is made.
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Hexokinase catalyzes step 1. Step 1 releases a lot of energy (therefore is essentially irreversible). ( G = -16.7 kJ/mole)
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G for this step is very small. This means the reactant and product are present in almost equal amounts at equilibrium. Step 2. Catalyzed by phosphoglucose isomerase.
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Oh no, we just used another ATP! Aren’t we supposed to be making ATP? We are still on the “preparatory phase”. Notes on step 3: G = -14 kJ/mol, so energetically very favorable, therefore not reversible. This step is a key regulatory point for regulating glycolysis (high levels of
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This note was uploaded on 06/20/2011 for the course CHEM 369 taught by Professor Hoffman during the Spring '11 term at University of Texas at Austin.

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3_sp11_glycol_notes - Can you identify these molecules ?...

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