ch369_sp11_lipid_metab_2_notes

ch369_sp11_lipid_metab_2_notes - Lipid metabolism - Part...

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Lipid metabolism - Part II. (continuing in chapter 16 or 14)
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In the mitochondrial matrix, fatty acids (FAs) are oxidized 2- carbon units at a time, by “ beta oxidation ” (a 4-step enzyme catalyzed cycle).
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Can enter TCA cycle. Lots of energy is released in oxidizing fatty acids !
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Some fatty acid metabolism occurs in special organelles inside cells called “ peroxisomes ”. Peroxisomes oxidize branched-chain fatty acids, and FAs that are too long to be handled by the mitochondria (too long is approx. > 22 carbons). Fatty acid metabolism in peroxisomes.
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peroxisomes - wikipedia. Peroxisomes are small intracellular compartments.
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Phytanate is obtained in our diet from green plants. Example of a branched chain FA that is metabolized in peroxisomes.
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Chlorophyll a is a source of phytanate. It is found in photoreceptors in chloroplasts in green plants. source of phytanate chlorophyll a
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Peroxisomes - containers that hold hazardous reactions. Peroxisomes contain enzymes that can degrade branched chain FAs. The can also do beta oxidation. In peroxisomes, the electrons from FA oxidation are transferred to O 2 which yields H 2 O 2 (peroxide). H 2 O 2 is toxic if it gets outside of peroxisomes. An enzyme “ catalase ” converts H 2 O 2 to water and O 2 Fatty acid metabolism in peroxisomes.
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water & oxygen catalase
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is a defect in degrading branched FAs. There is excess accumulation of phytanate in cells. Symptoms in early childhood; results in brain damage if untreated. Treatment is to restrict diet to avoid plants that contain significant amounts of
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This note was uploaded on 06/20/2011 for the course CHEM 369 taught by Professor Hoffman during the Spring '11 term at University of Texas at Austin.

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ch369_sp11_lipid_metab_2_notes - Lipid metabolism - Part...

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