DNA Repair - Homologous recombination is a repair mechanism...

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Homologous recombination ” is a repair mechanism that can fix double-strand breaks . Proteins that coordinate this repair process are always present in bacteria and eukaryotes (they are constituitively expressed ”). BRCA1 (a breast cancer associated protein) participates in DNA break repair. Mutations in BRCA1 compromise the repair mechanism, resulting in higher breast cancer risk. Figure 18-12.
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HPV infects cells in skin and mucous linings (especially cervix). HPV strains #16 and #18 produce E6 and E7 proteins that have particularly high affinity for binding to our P53 and RB proteins. These are the most dangerous strains of HPV. While a person has an HPV infection, their DNA repair mechanisms are disrupted, due to viral E6 and E7 proteins binding to our P53 and RB. Disruption of P53 & RB function increases the chances that cells with damaged DNA can replicate. How do high-risk HPV strains promote cervical cancer?
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This note was uploaded on 06/20/2011 for the course CHEM 369 taught by Professor Hoffman during the Spring '11 term at University of Texas at Austin.

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DNA Repair - Homologous recombination is a repair mechanism...

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