lecture 11 - Glycolysis and Respiration The Role of the...

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Glycolysis and Respiration
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The Role of the Krebs Cycle in Biosynthesis The diagram shows the path of carbon flow through the Krebs cycle to important molecules of life
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Glycolysis Glucose Glucose-6-P Fructose-6-P Fructose-1,6-bisphosphate glyceraldehyde 3-phosphate Two 1,3-bisphosphogycerate Two 3-phosphoglycerate Two 2-phosphoglycerate PEP Pyruvate ATP 2 ATP ADP ADP 2 ADP 2 ADP 2 NAD + 2 NADH Acetyl CoA 2 NAD + 2 NADH Mitochondria CO 2 CoA hexokinase phosphogluco-isomerase phosphofructo-kinase aldolase Dihydroxyacetone-P isomerase glyceraldehyde 3-P dehydrogenase PGA kinase mutase enolase pyruvate kinase Highly regulated
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Photosynthesis to starch synthesis Glucose-6-P Fructose-6-P Fructose-1,6-bisphosphate glyceraldehyde 3-phosphate Two 1,3-bisphosphogycerate Two 3-phosphoglycerate 2 ATP 2 ADP 2 NADP + 2 NADH phosphogluco-isomerase fructose-1,6- bisphosphatase aldolase Dihydroxyacetone-P isomerase glyceraldehyde 3-P dehydrogenase PGA kinase P i H 2 O A critical regulated step to sucrose synthesis
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The Krebs Cycle A mitochondrion Entry Points for Carbon: 1. Citrate synthase 2. PEP carboxylase PEP HCO 3 OAA 2 PEPCase Citrate synthase 1
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Mitochondrial Electron Transport H + H + Complex III (Cyt b) Note: proton flow is not through Cyt b as indicated, but by reduction and oxidation of ubiquinones (Coenzyme Q) H + Protons do flow directly via complex I and IV
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Complex II H + Complex III (Cyt b) H + Complex II H + C II Fumarate Succinate The FAD that is reduced is bound inside complex II. Complex II is succinate dehydrogenase in the Krebs cycle Complex II: The succinate dehydrogenase from the Krebs Cycle
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ATP Synthesis
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Mitochondrial vs. Photosynthetic Electron Transport Similarities – many shared elements 1) Mobile quinones are used to move electrons between high energy state protein complexes and a cytochrome b complex in the membrane 2) Mobile quinones transport protons across the membrane 3) A cytochrome complex sits in the middle of the electron transport chain, and operates a Q-cycle 4) A soluble electron carrier connects cytochrome complexes to the next complex in the chain 5) Water and O 2 are involved
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Mitochondrial vs. Photosynthetic Electron Transport Mitochondrial Electron Transport Photosynthetic Electron Transport
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Mitochondrial vs. Photosynthetic Electron Transport Differences: they are not simply electron transport schemes operating in reverse directions 1) Complex I and IV are fundamentally different from PSII and PSI 2) O 2 receives electrons to form water in respiration 3) The small mobile electron carrier plastocyanin is not cytochrome C 4) NADH donates electrons in mitochondria; NADPH is employed in chloroplasts 5) Different quinones – similar in structure, but different molecules. NOTE: Photorespiration and mitochondrial respiration are completely different processes.
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This note was uploaded on 06/21/2011 for the course BIO BIO251 taught by Professor Busch during the Fall '11 term at University of Toronto.

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lecture 11 - Glycolysis and Respiration The Role of the...

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