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ANA300 - 9:19 AM <-overall high in collagen little tissue...

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(appears pink in H&E) <--overall, high in collagen & little tissue fluid <-- tissue fluid: medium for diffusion between cell & blood <-- form of crystal (calcium is stored in bone) September 27, 2010 9:19 AM Bone Page 1
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( 4 main characteristics) Cells busily produced protein and product and secrete is known as "osteoid" Osteoblast is full of endoplasmic reticulum , golgi& acidic (attracts basicphilic --> hence, appears blue in H&E). Cuboidal to squamous depends on the level of activities Differentiation from osteoblast to osteocyte occurs when osteoblast is completely surrounded by matrix. The matrix becomes calcified --> Long arms extend into matrix . The channels are called "canalicula". This allows the continuous communication via gap junction. i.e. reaction to tensional forces Bone is dynamic --> it functions to maintain the bone tissue & react to mechanical stresses Osteoclast is from a different cell lineage. Monocyte lineage (like microphage do) Multi nuclear (b/c they are formed by union of 5 monocyte) Found on bone surface "Howship's lacuna" e (like CT, starting point is mesenchymal cells) Bone is highly metabolic tissue but cartilage has no oxygen supply. Therefore, cartilage produced energy in anabolic manner. Under a favorable conditions, osteoprogenitor cells will differentiate into osteoblasts but in unfavorable condition (i.e. Low oxygen & tension), it will differentiate into chondroblasts. Why? - (Osteoid is the organic component of the matrix. It included colalgen, glycoproteins, etc. Long arms extend through matrix Canaliculi = small channels which cell processes occupy. It allows contact & communication Bone takes up the shape given the stress imposed upon it The process is know as "osteolysis" Enzyems and acid are secreted to microenvironment to dissolve the bone. To release greater enzyme and acids to speed up the breakdown of the bone Bone Page 2
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Bone Page 3
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Creation of bone from mesochyand role or different cells in creation of bones Bone is an organ Lamellar --> form of layers of bone tissue found on outer surface (cortex) of all bones Mesenchymal cells --> Osteoblast active lays down osteoid. The active ones are represented taller. Osteoid is found on the surface of the bone. This will subsequently be calcified. Osteoclast is multinuclear. <-- these will become osteocyte by being surrounded by matrix <-- found in inside of the bone Long bone --> i.e. bones in limbs Short bone --> i.e. bones in wrist Flat bone --> i.e. surface of the skull Irregular bone --> i.e. form by union of smaller bone (vertebrate) & hip bone i.e. knee cap Developed due to friction Bone Page 4
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(end of the bone ) (thick-yellow line). (white space filled with yellow marrow Acts as "storage" for adipose (blood supply) Only nutrient As & Vs illustrated Each bone has single vessel. It goes through a hole and keeps running (i.e. nutrient artery vein) Cortical bone supply comes within not from outside Compact bone is highly organized.
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