CT & Cartilage - Epithelia has little...

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Unformatted text preview: Epithelia has little functionality, cell composed Cells define epithelium (i.e. yellow filling & thin pink threads on the picture) <-- where matrix comes from (cells are able to move further apart) (i.e. blood [liquid] --> bone [solid] **major difference from epithelia** Cells differentiate differently to produce different proteins- i.e. "fibroblasts" --> "-blast" used for immature cells actively producing matrix i.e. "fibro cyst" --> "-cyst" used for cells that maintain matrix but inactive at production Fibro : "fiber"- Chondro : "cartilage"- Osteo : "bone"- CT & Cartilage - 09/27 ~ September 22, 2010 5:53 PM CT & Cartilage Page 1 Every CT has different proportion of fibres but has continuum Fibres Tissue fluid = Extracellular fluid (ECL) bound by organic molecules (strong resistance) (react to tensile forces but will bounce back once tension is removed) (include blood) <-- produced by cells of CT (bind tissue fluid) <-- hold everything together (organizes CT) (has binding sites for fibres, cells, proteoglycans, etc.) Tendon connects muscle to bone 1. Rich in collagen - Resistance to tensile force- Bundle of fibre makes up tendon 2. Fibre is composed of fibril 3. Fibril is composed of tropocollagen 4. ("Collagen Type 1" is most abundant) (forms in extracellular space) Tropocollagen has polarity & self- assemble to line up spontaneously Fibril forms after completion of tropocollagen lining <-- each line represents tropocollagen (most collagen forms fibre but NOT ALL)--> reason for the term "fibrillar" CT & Cartilage Page 2 Gap region: responsible for banding patterns Collagen type 1: collagen fibrils form fiber Ultimately forms ligament Some steps are intercellular and others occur extracellulary- collagen molecules consist of 3 alpha-chains forming a helix <-- transported cytoplasm (intracellular process) Protein is produced in association with ER. Produced within RER = alpha chains isolated Preprocollagen(alpha chains) modified and hydroxylated and carbohydrate molecules added i.e. case of Scurvy Hydroxylation is vitamin-C dependent - Triple helix = procollagen No formation of alpha helix Maintaining solubility = does not self-assemble <- by transport vesicles <-- important process of registration peptides removal ** Procollagen molecule is converted to tropocollagen by peptidases Without registration peptides, tropocollagen can now self-assemble Tropocollagens make-up fibre. Reason for strong tensional resistance Alignment of tropocollagen & crosslinks make it very strong CT & Cartilage Page 3 (know "where" and "what" makes each different!!)(know "where" and "what" makes each different!...
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CT & Cartilage - Epithelia has little...

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