PHARMAC 3B06 - 2009-2010 (Werstiuk)

PHARMAC 3B06 - 2009-2010 (Werstiuk) - METHODS IN...

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1 METHODS IN PHARMACOLOGY, 2009-2010 Introduction. ..................................................................................................................... 2 General Outline. ................................................................................................................ 3 Evaluation Guidelines. ....................................................................................... ………. . 4 Personnel. ......................................................................................................................... 6 Schedule: Part 1. ............................................................................................................... 7 Lab Safety. ........................................................................................................................ 8 Skills Objectives. ............................................................................................................... 9 Academic Dishonesty. ....................................................................................................... 9 Exercise #1 - Quantifying drug action on isolated tissues The effect of muscarinic acetylcholine receptor drugs on porcine urinary bladder contractility in vitro. ............................................................................................... 10 Exercise #2 - Quantifying drug / receptor binding The effect of drugs on the binding of [ 3 H]Quinuclidinyl benzilate to porcine urinary bladder membranes……………………………………………………… 14 Exercise #3 - Drug discovery Development of a cell-based assay for drug screening. .......................................... 20 Exercise #4 - Electro-pharmacology Patch clamp methods for the determination of the mechanism of drug action…. .. 22 Exercise #5 - Quantifying drug action on enzymes A fluorimetric screen to identify inhibitors of ethoxyresorufin deethylase (EROD) . ............................................................................................ 24 Guidelines for the Discovery Project Report. .................................................................... 30 Solutions. .......................................................................................................................... 32 Samples of Evaluation Documents. .................................................................................. 33 Twenty one ways to drop marks in lab reports. ................................................................ 38
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2 INTRODUCTION Pharmacology is an experimental discipline and we are going to teach you some experimental skills . You will also be expected to learn to interpret experimental data , to design your own experiments and to communicate your results . You will simultaneously be developing relevant knowledge through your work in 3A06. These two courses, 3A06 and 3B06 are companion courses in the truest sense and you must be prepared to transfer learning from one to the other throughout
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PHARMAC 3B06 - 2009-2010 (Werstiuk) - METHODS IN...

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