Lecture 3 outline

Lecture 3 outline - Biology 2A03 Lecture # 3 Protein...

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1 Biology 2A03 Lecture # 3 Protein activity
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2 Tight Junctions Fig 2.26 -Extracellular membranes of adjacent cells joined -Transport pathway between cells (extracellular) blocked -Most substances must therefore go transcellularly - Forms a selective barrier -E.g. most epithelial cells Cell – cell contact (adhesions)
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3 Desmosomes Fig 2.27 -Hold adjacent cells tightly together -found in areas of stretching (e.g. skin ) or high mechanical stress ( cardiac cells )
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4 Gap Junctions Fig 2.27 - Protein channels ( connexons ) linking cytosols of adjacent cells - concentrated in cardiac cells at inter- calated disks & important for passage of electrical signals (Fig 14.8) - channels are very small (1.5nm diameter) & limits what can pass
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Protein activity Proteins and protein function central to physiology Protein activity is controlled by: 1) Rates of 2)Changes in (Determined by amino acid composition) -Important for ligand binding to binding site The shape of proteins and therefore modified by:
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Lecture 3 outline - Biology 2A03 Lecture # 3 Protein...

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