Lecture 4 outline

Lecture 4 outline - Biology Lecture 4 Protein activity...

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1 Biology Lecture 4 Protein activity (cont. .) Transport I
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2 Michaelis-Menten equation : V 0 = [S] Vmax Km + [S] Relationship between [S] and reaction rate The quantitative description of enzyme reaction rates to [S], constants Vmax and Km occurs by the: V 0 [S] ½ Vmax Km 1 Vmax Km = substrate concentration ([S]) at which V 0 = ½ Vmax If affinity increases then the # of ES complexes increase at any given [S] or the same # of [ES] at lower [S] (i.e. Km decreased) In other words at high affinities ½ Vmax occurs at a lower [S] Km can be determined from this plot 1/Km = affinity Km 2
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3 Metabolic pathways A sequence of enzyme-mediated reactions leading to a specific product A B C D P E1 E2 E3 E4 Allosteric inhibition (end product inhibition) Specific reaction steps may be regulated to control flux through the entire pathway. Classically these are called “rate limiting” steps but modern control theory does not use this term - Looks at the relative control at each enzymatic step
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4 Metabolic Pathways ATP Synthesis One of the major roles of metabolic pathways is to convert the energy in food (stored as fuel) to ATP to power cellular functions
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Lecture 4 outline - Biology Lecture 4 Protein activity...

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