Lecture 5 outline - Biology 2A03 Lecture 5 Transport...

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1 Biology 2A03 Lecture 5 Transport Mechanisms II
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2 Fig 4.2 Separation of charge = potential energy Separation of Charge Across a Membrane –Electrical forces •Opposite charges attract •Like charges repel –Membrane potential is: negative (always relative to inside) •Electrical driving force on cations – into cell •Electrical driving force on anions – out of cell –Magnitude of electrical driving force depends on: •size of membrane potential •valence of ion
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3 Electrochemical Driving Forces Direction of ion movement depends on balance between If equal the electrochemical force is For this example : Chemical < electrical = Fig 4-5 E k = equilibrium potential
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4 Fig 4-13 Selective for type of ion -due to size and the charged and polar surfaces of the protein subunits of the channels Channel Protein Consist of polypeptides Opening of the pore can be regulated Electrically
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5 2b) Facilitated Diffusion (actually a mediated transport) Net flux of molecules across membranes is Not coupled with ATP hydrolysis Flux 1 >> Flux 2 ECF = ICF =
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