lect41slides - how it works in some detail 1 anchor cell...

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- how it works, in some detail EGF (epidermal growth factor) EGFR (epidermal growth factor receptor) activated Ras signal from Ras, involves several proteins transcription factor 1. anchor cell secretes EGF 2. EGF binds EGFR on Pn.p cells 3. EGFR activated, activates Ras 4. activated Ras inhibits transcription factors 5. lateral inhibition prevents 2° cells from adopting primary fate despite small amount of activation (lin-3) (let-23) (let-60) (lin-45, mek-2, mpk-1) (lin-1, lin-31)
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How was vulval development pathway deciphered? - genetic screens for vulvaless ( Vul ) and multivulvae ( Muv ) lin-3 let-23 sem-5 let-60 lin-45 mek-2 mpk-1 lin-1 lin-31 1°vulval
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This note was uploaded on 07/01/2011 for the course L 311 taught by Professor Forrester during the Fall '10 term at Indiana State University .

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lect41slides - how it works in some detail 1 anchor cell...

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