Link_Diseq_L567.xls(z=1)

Link_Diseq_L567.xls(z=1) - recomb sa sb z 0.25 0.99 0.99 0...

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recomb 0.25 <-- change this value to change the recombination freq. sa 0.99 <-- change this value to change selection against the a allele sb 0.99 <-- change this value to change selection against the b allele z 0 <-- change this value to 1 to get independent effects of selection on a and b for values > 1, the ab genotype is less fit than expected for values < 1, the same type is more fit than expected Linkage disequilibrium Epistasis There are two haploid loci, each with two alleles D E There are four genotypes: AB, Ab, aB, ab p(ab)*p(AB) - p(aB)*p(Ab) ln([Wab*WAB]/[WaB*WaB]) Freq of or or genotype--> A-------B A-------b a-------B a-------b A B p(ab) - p(a)*p(b) ln(Wab) - ln(WaWb) N. individuals before selection 25 25 25 25 100 pij = Freq before selection 0.25 0.25 0.25 0.25 1 0.50 0.50 0.000 Wij = fitness of genotype 1 0.01 0.01 1.00 9.2103 Calculation of Wij 1 (1 - sb) (1 - sa) [(1-sa)(1-sb)]^z Freq after selection: Wij*pij 0.250 0.003 0.003 0.250 0.51 0.50 0.50 Normalized freq= Wij/Wbar 0.495 0.005 0.005 0.495 1.0 0.50 0.50 0.2450 0.2450 0.2450495 Freq, after free recombination equal to (1-r)*pij + r*pi*pj 0.434 0.066 0.066 0.434 1.0 0.50 0.50 0.1838 Note, the effect of free recombination was to reduce linkage disequilbrium.
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