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Lecture 5-07a - L312/Spring 2007 Lecture 5 Drummond Read...

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L312/Spring 2007 Lecture 5 Drummond Read Chapter 12 on movement across membranes I failed to get the 1/2 study guide up; I’ll remedy that today with at 5/8th guide. Last time: How do proteins span membranes? The role of helices and sheets How can TM helices with outer-facing hydrophobic residues make selective pores? The K+ channel: selectivity filter for a single ion. Sheet structures (large pores/toxins) Membranes compartmentalize the cell; TM proteins support traffic Uniporters, symporters, antiporters describe direction of movement Passive vs active transport (gradient vs ATP-driven) Glucose movement through basal epithelial cells is based on transporters Today: Transporters to move materials across membrane glucose uptake in more detail role of carbohydrates on the cell surface sodium/potassium antiport mechanism how can one measure ion movement?
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Look closely at where the charged and polar residues lie what is the overall charge of each ‘head group” Why do double bonds in the membrane increase fluidity?
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