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Lecture 6-07 - L312/Spring 2007 Lecture 6 Drummond For...

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L312/Spring 2007 Lecture 6 Drummond For today: Be sure to be reading Chapter 12 focus today on pages 403-423: Ion channels and action potentials Key points from the last lecture: Uptake of glucose from gut epithelial cells a. At least three transporters (a symporter, antiporter, uniporter--what are they?) are essential for the uptake of glucose and passage into the bloodstream b. Concentration gradients drive most movements across membranes; ATP is essential for transporters that function against gradients c. The membrane has key features: impermeable, specific sites where materials can pass selectively, and movement of ions across the membrane may be coupled in a useful way to cellular function (making ATP, importing glucose, etc). d. The mechanism of the Na + /K + antiporter is cyclic, ATP dependent, and toggles between two states, one open to each space. Oh--and 3Na + /2K + exchanged. e. FRAP as a technique to monitor diffusion of proteins and lipids within cells Today: a.
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