Lecture 11-07web

Lecture 11-07web - L312/Spring 2007 Lecture 11 Drummond Feb...

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L312/Spring 2007 Lecture 11 Drummond Feb 15 Exam: Returned at the end of class. The exam and key are on the web. For today: Still focus on Chapter 15, Ch. 16 497-511: Protein sorting See also p. 183-184 (chromosome structure in the nucleus) Look at questions 15-4, 15-5, and 15-6 (answers in back) Don’t forget about next drawing assignment (posted today) Last time: The cell comprises densely packed membrane-enclosed spaces (nucleus, golgi, ER, etc). Information that directs a protein to a specific cellular space is inherent to the primary amino acid sequence (called signal sequences). Nuclear transport is passes double lipid bilayer (nuclear envelope) via nuclear pores transporters bind signal sequences, cargo is displaced by Ran-GTP process is driven by GTP hydrolysis (positively charged patch is signal) Mitochondrial import passes two sequential lipid bilayers signal sequence binds transmembrane receptor, migrates in membrane fusion with inner membrane counterpart allows import as denatured protein
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Lecture 11-07web - L312/Spring 2007 Lecture 11 Drummond Feb...

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