Lecture 12-07web

Lecture 12-07web - L312/Spring 2007 Lecture 12 Drummond Feb...

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L312/Spring 2007 Lecture 12 Drummond Feb 20 For today: Focus on Chapter 15, 512-529: Vesicular transport The role of clathrin and snares in transport Structure and function of the Golgi apparatus Next: Chapter 17, 574-591: Cytoskeletal elements see also Chapter 4 pages 134-135, 121-125 on protein structure If you didn’t get your exam, pick it up after class (and old drawing exercises) Distinguish: nuclear transport (through a pore; must pass TWO membranes) from organellar import (e.g., into mitocondrion by denaturing; again, must pass TWO membranes). from co-translational import (expressing protein into ER lumen) from ( today ) movement via vesicles (membrane coated bodies) Compare: transport across mitochondrial membranes with transport across the ER membrane Follow transmembrane proteins as a way to understand vesicular transport
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How is a single pass transmembrane protein inserted in the membrane? (for example, receptor tyrosine kinases--and how would they get to the PM?)
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Lecture 12-07web - L312/Spring 2007 Lecture 12 Drummond Feb...

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