Lecture 14-07-web

Lecture 14-07-web - L312/Spring 2006 Lecture 13 Drummond...

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L312/Spring 2006 Lecture 13 Drummond Feb 27 For today: Focus on Chapter 17, 579-592: Microtubules, kinesin and dynein Last time: Intermediate filament structure and function single proteins (~50 nm) form helical secondary structure monomers dimerize as coiled coil proteins (how) dimers form staggered tetramers staggered tetramers form filaments (compare to thread make-up) 8 filaments form a ‘seven around one’ twisted cable crucial for structural integrity (cell, nuclear lamina) Formation is REVERSIBLE based on phosphorylation status Today: Look at microtubules (hollow but rigid polymers) why hollow? Are these for strength? where are they found, and what do they do? how are they stabilized and capped? how do motor proteins (kinesins and dyneins) interact with them? Broader question: what do microtubules contribute to cellular function?
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What are the structural needs of a cell? Shape Cellular movement Organellar structure what gives the nucleus structure? Organellar movement
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This note was uploaded on 07/02/2011 for the course BIO-L 312 taught by Professor Drummond during the Fall '07 term at Indiana.

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Lecture 14-07-web - L312/Spring 2006 Lecture 13 Drummond...

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