Lecture 18-07web

Lecture 18-07web - L312/Spring 2007 Lecture 18 Drummond...

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L312/Spring 2007 Lecture 18 Drummond March 27 For today: Focus on Ch. 18 Cell cycle regulation (611 - 625) st time: DNA is highly compacted wrapped around histone octamer (eight histone proteins) DNA + histones = nucleosome histones form ‘beads on a string structure’ beads on a string folds into a 30 nm width fiber further compacted into chromatin How does the cell ‘remember’ where specific genes are? How are genes marked for expression at a specific time? The histone code: Histone tails (N-termini of protein) are modified specific sites are modified; focus on lysine (K) and serine (S) the ‘code’ corresponds to DNA compaction or availability heterochromatin=poorly accessible/compacted DNA euchromatin=accessible/actively transcribed regions Organization of the nucleus and DNA in the nucleus day: Specific views of cell cycle control and checkpoint arrest focus on why arrest or progression might be appropriate focus on the mechanism of arrest or progression
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Levels of chromosomal organization
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Identification of the histone and nucleosome core components Distinguish Histones from nucleosomes
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An introduction to the ‘histone code’ What are these amino acids?
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This note was uploaded on 07/02/2011 for the course BIO-L 312 taught by Professor Drummond during the Fall '07 term at Indiana.

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Lecture 18-07web - L312/Spring 2007 Lecture 18 Drummond...

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