Lecture 19-07web

Lecture 19-07web - L312/Spring 2007 Lecture 19 Drummond...

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L312/Spring 2007 Lecture 19 Drummond March 29 For today: Finish Ch. 18 Apoptosis and Growth (625 - 633) Exams back Today! Hooray! Last time: cell cycle control and checkpoint arrest Cyclins + cdk (cyclin dependent kinases) regulate key cell cycle events Ubiquinylation (adding the small protein ubiquitin) is a signal for the protein to enter the proteasome cyclins are degraded by Ubq/proteolysis after cell phase initiation Again: focus on protein/protein or protein+modification events that underlie the specific events in question. Today: Apoptosis! (Programmed Cell Death = PCD) compare microorganisms versus complex organisms the machinery that degrades the cell and its regulation (an ordered, irreversible cascade) Cell growth signals relationship with apoptosis how is cell proliferation achieved?
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It couldn’t be that simple: phosphorylation status is crucial to M-cdk The key here is that phosphorylation at specific sites is crucial for function. Multiple required inputs exponentially increases the level of complexity for regulation.
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This note was uploaded on 07/02/2011 for the course BIO-L 312 taught by Professor Drummond during the Fall '07 term at Indiana.

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Lecture 19-07web - L312/Spring 2007 Lecture 19 Drummond...

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