Lecture 20-07web

Lecture 20-07web - L312/Spring 2007 Lecture 20 Drummond...

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L312/Spring 2007 Lecture 20 Drummond April 3 For today: Begin Ch. 19 Mitosis and cytokinesis Old exams/drawing exercises available after class Last time: Apoptosis (Programmed Cell Death = PCD) (an ordered, irreversible cascade) virtually every major structure is degraded within intact PM caspase cascade is initiated (caspases X, Y and Z) what are these? small protein regulators (bax, bak) form membrane channels, mediate cytochrome c release from mitochondria (bax, bak are bcl-2 family members) bcl-2 inhibits apoptosis, prolongs survival window Today: distinguish between mitogens, growth factors and survival factors mitogens activate cyclins, phosphorylate Rb (among others) growth factors modulate protein degradation/synthesis survival factors block apoptosis for specific cells Mitosis (high school biology, revisited) with emphasis on molecular details special attention to: roles and structures of filaments DNA compaction cellular structures
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Apoptosis revisited What happens to the mitochondria during apoptosis? What are the roles of the bcl-2 family of proteins?
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This note was uploaded on 07/02/2011 for the course BIO-L 312 taught by Professor Drummond during the Fall '07 term at Indiana.

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Lecture 20-07web - L312/Spring 2007 Lecture 20 Drummond...

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