Lecture 23-07web

Lecture 23-07web - L312/Spring 2005 Lecture 23 Drummond...

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L312/Spring 2005 Lecture 23 Drummond April 12 or today: Still Chapter 21! How are cells connected? Note: Study guide to be updated after today’s lecture (Exam 3 in one week). Last time: Cells in the context of tissues (focus on connective tissues) What and where is the extracellular matrix? What are the primary protein and carbohydrate components? collagen and GAGs (glycosamino glycans) collagen: long, overlapping filaments (banded appearance) these are heavily crosslinked (essential) contain unsusal amino acids (hydroxyproline/hydroxylysine) that support the chemical crosslinking/oxidized in situ Today: Focus on connections between cells (mostly epithelial layers (tissue)) tight junctions claudins and occludins adherens junctions actin bundles connected by cadherins desmosomes intermediate filaments (keratins) con. by cadherins hemidesmosomes keratins connected to integrins con. to basal lamina gap junctions connexins span four membranes to form pore
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Collagen fibrils in: skin bone Space filler: Ca 3 (PO 4 ) 2 Exocytosis to deposit collagen outside cell
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Chick heart tissue organizing collagen fibers Moving fibroblasts How might extracellular signals modulate this?
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This note was uploaded on 07/02/2011 for the course BIO-L 312 taught by Professor Drummond during the Fall '07 term at Indiana.

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Lecture 23-07web - L312/Spring 2005 Lecture 23 Drummond...

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