10-2Ch102009Students

10-2Ch102009Students - Chapter 10 Manipulating Molecules...

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Chapter 10 Manipulating Molecules and Designing Drugs Monday, 28 September 2009 Readings Chapter 10.3 – 10.4 Homework: Questions 15-22, 37-40 Functional groups play a role in _________, an important consideration for uptake, rate of reaction and residence time of drugs in the body “Like dissolves like” Polar molecules have a nonsymmetrical ______ distribution, leading to the build-up of _______ +ve and –ve charges, ! + , ! Polarity with O N Increases ______ solubility
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Compounds that do not contain many functional groups are typically ___________. E.g., _________ This leads to insolubility in water and accumulation in cell membranes and fatty tissues, which are largely hydrocarbon and nonpolar, i.e., _________.
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Solubility properties lie on a _____________ Water solubility can be __________ by protonation with H + . Compounds containing functional groups that are alkali, or basic, and when the basicity is conferred by a nitrogen, e.g., ______, are called the ____________ form. The ________ can be converted into the ____ by an acid/base reaction. N CH 3 H CH 3 OH H Cl N CH 3 H CH 3 OH H + Cl Pseudoephredrine (_________) Pseudoephredrine hydrochloride _____ N CH 3 H CH 3 OH H + Cl The resulting positive charge on ____ is balanced by the chloride, Cl , ion. This is an _______ compound, e.g., NaCl, common table salt. The ___ form is preferable as a drug because it is more stable, has less odor and is _______ soluble. About half of the drugs are used as salts. Note: revert back to freebase by treating with base, e.g., NaOH.
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Drugs with similar physiological properties often have similar molecular structures and include the same functional groups. _______ + _____ functional
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10-2Ch102009Students - Chapter 10 Manipulating Molecules...

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