10-3Ch102008Students

10-3Ch102008Students - Chapter 10 Manipulating Molecules...

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Chapter 10 Manipulating Molecules and Designing Drugs Wednesday, 30 Sept 2009 Readings Chapter 10.4 – 10.6, 10.11 Homework: Questions 15-22, 37-40 23-26, 41 Drugs can be classified into two groups: Cause __________ responses _______ growth of substances that cause infections e.g., NAIDs, hormones psychologically active drugs e.g., __________ Yet, most drugs only act against certain diseases or infections They are _________. WHY? 1. The general ________ of the molecule (drug), and 2. the ______ and _______ of its ____________ are both ideally suited to interact with specific receptor sites on biological molecules
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Although biological molecules are large, they usually have one small ___________ that is responsible for everything they do (usually one thing) Drugs are usually designed to _______ or _____ this function by interacting with the receptor site directly, or by binding to another location that influences the site indirectly. The coenzyme folic acid (L) and the anti-cancer drug methotrexate (R) are very similar in structure. As a result, methotrexate is a ________________ of many enzymes that use folates. Lock-and-Key Model e.g., Assume the ____ acts to control the passage of ions across a cell membrane. Whether the ___ (drug or hormone) is bound, controls this pathway, therefore, controlling the biochemistry inside the cell As with locks and keys, a ____________ is required between molecules and their targets to influence cellular activity.
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Some ________ is present and the binding site can often accommodate _______ or ________ molecules… In these cases, the substrate __________ model may also play a role. The _________ is the name for the substance whose reactions are catalyzed by the enzyme.
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