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Immunology 2.4.10 - Corticosteroids UVA tar Coal UVB...

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f the market due to PML (Progressive Multifocal Leukoencepholapathy) UVA UVB Topical/phototherapy Corticosteroids Coal tar Anthralin Calcipotriene Tazarotene Immunology Dr. Ghazvini February 4, 2010 Psoriasis Chapter 101 in Dipirro The more common dermatological disorder we will encounter. Common chronic disease characterized by Occurs in the epidermis Keratinocytes- keratin- forms hair and nails Normal cell growth o Cells mature and migrate from the bottom layer to the surface and are shedded, normal process takes about a month o In psoriasis keratinocytes proliferate rapidly travel from the basal layer to the surface in 4 days, and the skin cannot shed these cells quickly enough so they accumulate and turn into thick dry, scaly, patchy lesions. Over production of B-cells and T-cell o IL-2, IL-6, IL-8, IL-12, IL-12 Neutrophils stimulate the production of avachidonic acid which triggers about 30 different chemicals which play a role in inflammation. Possible etiologic factors in Psoriasis o Defects in epidermal cell cycle o Genetics o Exogenous trigger factors Climate Stress Infection Drugs
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Lithium – associated with new onset and may contribute to resistance Inderal NSAIDS Penicillin Tetracycline Sulfonamides Salicylates Abrupt withdrawal of systemic corticosteroids – psoriasis flares Types of Psoriasis o Plaque- most commonly seen in patients that come into pharmacy
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  • Spring '10
  • Ghazvini
  • pustular psoriasis, Corticosteroids UVA tar, psoriasis keratinocytes, Coal UVB Anthralin, remission UVA +Calciprotriene

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