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lec08 - blood protein HbA/HbA viable not sickled HbA made...

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Picture 20 Picture 28 blood protein Hb A /Hb A viable not sickled Hb A made Hb A /Hb S viable partly sickled both Hb A & Hb S Hb S /Hb S lethal all sickled Hb S made Lecture 8 – Genetic analysis/Modifications to Mendelian ratios I. Gene products may not act independently A. pleiotropy –  eg. fly  white  gene B. many genes may affect single trait C. How can many genes affect one trait? - consider hypothetical pathway for red pigment production - many steps required to make  product - each step catalyzed by different enzyme (1, 2, 3……) - so, often, many genes are required to synthesize a single product II. Test for allelism Q. If many genes can contribute to single product, how do we know if 2 mutations causing same  phenotype are in same gene? A. We use a simple genetic test, called a complementation test 1. How does complementation test work?
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