lec15 - Lecture 15 epigenetics I. Some genetic effects are...

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Lecture 15 – epigenetics I. Some genetic effects are not mediated by changes in DNA sequence A. epigenetics – 1. can be mediated by protein expression 2. often mediated by DNA/histone modification 3. stably maintained through cell division II. Examples of epigenetic effects: A. cell differentiation, eg. muscle cell differentiation - differentiating muscle expresses myoD B. genomic imprinting 1. What is it? - copy of gene inherited from one parent is silenced 2. How? DNA methylation  3. Why? competition in utero - only mammals 1
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- females of many species have multiple mates - male’s interest that his offspring biggest but female’s interest that offspring not  too big - predicts that  imprinted genes should regulate growth, often but not always true 4. eg. Mouse 5. human: Prader-Willi vs Angelman syndromes - Prader-Willi: mild mental retardation, obesity, diabetes -Angelman: behavioral disorder, mental retardation 2
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This note was uploaded on 07/01/2011 for the course L 311 taught by Professor Forrester during the Fall '10 term at Indiana State University .

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lec15 - Lecture 15 epigenetics I. Some genetic effects are...

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