lec16 - Lecture 16 gene mutations I. Gene mutations A....

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Unformatted text preview: Lecture 16 gene mutations I. Gene mutations A. Change from wild type 1. forward mutation 2. reverse mutation (reversion) 3. mutation B. Types mutations 1. basepair substitutions a. at DNA level i. transition Picture 62 ii. transversion Picture 63 b. at protein level i. silent mutation ii. synonymous mutation iii. missense mutation iv. nonsense mutation 2. frameshift 1 Picture 44 C. Molecular basis of mutation examples Picture 46 Picture 45 II. Somatic vs germ line A. somatic mutation 1. if in dividing cells recessive dominant the earlier in development the mutation arises, the larger the mutant sector will be 2. if in nondividing cells most likely to have little or no effect an exception is cancerous mutation 3. can somatic mutation be passed to progeny? note that in plants germ line produced by somatic cells 2 B. germ line mutation III. Mutant types A. lossoffunction (null) null = no gene function B. gainoffunction generally dominant IV. Are mutations induced by selective conditions? A. mutations are relatively random events some mutations adaptive permit growth under selective conditions (eg. phage resistance) B. preexisting mutations are selected for several experiments showed that mutations already present in population Picture 48 How was this demonstrated? Replica plate (lederberg) C. spontaneous mutation rates 3 1. E. coli 2. Drosophile yellow 3. human 4 ...
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lec16 - Lecture 16 gene mutations I. Gene mutations A....

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