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lec16 - Lecture 16 gene mutations I Gene mutations A Change...

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Picture 62 Picture 63 Lecture 16– gene mutations I. Gene mutations A. Change from wild type 1. forward mutation 2. reverse mutation (reversion) 3. mutation B. Types mutations 1. base-pair substitutions a. at DNA level i. transition ii. transversion b. at protein level i. silent mutation ii. synonymous mutation iii. missense mutation iv. nonsense mutation 2. frameshift 1
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Picture 44 Picture 46 Picture 45 C. Molecular basis of mutation - examples II. Somatic vs germ line A. somatic mutation 1. if in dividing cells - recessive - dominant - the earlier in development the mutation arises, the larger the mutant sector will  be 2. if in non-dividing cells - most likely to have little or no effect - an exception is cancerous mutation 3. can somatic mutation be passed to progeny?
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