lec17 - Lecture 17 Gene mutations; mechanisms and repair I....

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Picture 76 Picture 87 Lecture 17 – Gene mutations; mechanisms and repair I. Spontaneous mutations A. result from several sources 1. errors of replication a. DNA polymerase can slip b. other errors may occur during replication 2. spontaneous lesions a. depurination b.  deamination 1
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Picture 90 Picture 7 c. oxidative damage 3. transposons (discuss later) B. human diseases – expansion of repeats 1. fragile X syndrome generation copies most 1 st  male daughter son 2. expansion of trinucleotide repeat also seen in:   Kennedy disease,  myotonic dystrophy  Huntington disease II. Induced mutations A. Base analogs 1. chemicals similar to bases 2. examples: a. 5-bromouracil 2
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Picture 91 Picture 78 b. 2-aminopurine B. specific mispairing 1. Some chemicals alter base so that it can pair with incorrect partner. 3
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Picture 80 Picture 81 2. alkylating agents C. intercalators 1. Some chemicals insert themselves into  DNA, distortion affects fidelity of replication 4
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D. ultraviolet light
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lec17 - Lecture 17 Gene mutations; mechanisms and repair I....

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