lec18 - Picture Lecture 18 Chromosome Structure I. So what...

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Lecture 18 - Chromosome Structure I. So what is a chromosome? A. composed of chromatin - DNA + protein; forms  stable, ordered structure 1. 2.  II. Genomes – a brief overview A. chromosome number can vary greatly B. genome size Genome size in kb form estimated # genes Virus SV40 5 circular 5 Herpes simplex 152 linear T4 165 linear 300 Bacteria E. coli 4,700 circular 4,000 Eukaryotes S. cerevisiae 13,000 16 chromo. 6,000 C. elegans 100,000 6 chromo. 19,000 Arabadopsis 100,000 5 chromo. 25,000 D. melanogaster 165,000 4 chromo. human 3,000,000 23 chromo. 35,000 maize 4,500,000 10 chromo. Amphiuma 76,500,000 14 chromo. 1.  1
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Picture 5 2. 3. III. How do you get that much DNA into a cell? A. Here’s the problem: DNA in human chromosome I estimated 82 mm long, but nucleus only  ~10 µm (0.01 mm) in diameter B. Solution: careful packageing, how?  1. linear DNA (human chromosomes = 2 meters/cell)
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This note was uploaded on 07/01/2011 for the course L 311 taught by Professor Forrester during the Fall '10 term at Indiana State University .

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lec18 - Picture Lecture 18 Chromosome Structure I. So what...

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