lec20 - Lecture 20 Chromosomal abnormalities structural I....

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Picture 31 Lecture 20 - Chromosomal abnormalities – structural I. Types of abnormalities A. deletion B. duplication C. inversion 1. paracentric 2. pericentric D. reciprocal translocation 1. Robertsonian translocation – special type of translocation that fuses 2  acrocentric/telocentric chromosomes. E. position effects II. Chromosomal deletions A. effects of deletion B. How can you tell if deletion present? 1
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Picture 20 A. deletion mapping z /del zw2 /del w /del     –     –     +     –     –     –     +     –     –     +     –     –     +     –     +     +     +     + 2
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Picture 32 III. Duplication A. Duplication repeats part of chromosome B. Tandem duplications can be further amplified by unequal crossover C. A few points about duplications 1. How can you detect their presence?
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This note was uploaded on 07/01/2011 for the course L 311 taught by Professor Forrester during the Fall '10 term at Indiana State University .

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lec20 - Lecture 20 Chromosomal abnormalities structural I....

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