lec25 - Lecture 25 viral genetics I. Viral genetics an...

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Picture 68 Lecture 25 – viral genetics  I. Viral genetics – an overview A. what is a virus? 1 2.  B. life cycles 1. lytic 2. lysogenic C. two types of phage 1. virulent –  2. temperate –  D. recombination 1. general – recombination occurs anywhere along two homologous DNAs 2. site-specific – recombination occurs at specific sites 3. for phage, end result is integration into bacterial chromosome E. lytic growth 1. spread large # bacteria uniformly on plate 2. add small # phage 3. phage grow and lyse cells they infect 4. phage spread slowly 5. create plaque of lysed cells 1
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Picture 78 Picture 69 6. each plaque generally derived from single infecting phage II. Phage recombination mapping A. if 2 particles with different genotype infect same cell, can get recombination 1. frequency of recombination to  determine map  distance between genes III. Transduction A. discovery - Lederberg and Zinder testing for recombination in Salmonella 2
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lec25 - Lecture 25 viral genetics I. Viral genetics an...

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