lec35 - Lecture 35 Cell Cycle Control and Cancer Genetics...

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Picture 164 Lecture 35 – Cell Cycle Control and Cancer Genetics I. Cancers result from genetic alterations A. majority of cancers caused by somatic mutations 1. spontaneous mutations 2. environmental mutagens - UV light increases risk of skin cancer - cigarette smoke increases risk of respiratory tract cancer B. some predispositions to cancer are inherited C. definitions 1. oncogene 2. proto-oncogene 3. viral or cellular oncogenes 4. tumor suppressor II. Hallmarks of cancer A. excessive cell proliferation B. metastasis C. an overview: 1
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III. Cell cycle regulation A. Phases of the cell cycle 1. G1 – Gap between end of mitosis and DNA synthesis 2. S – DNA replication occurs 3. G2 – gap between DNA synthesis and mitosis 4. M – mitosis and cytokinesis 2
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Picture 192 B. How to study cell cycle control:  C. Cyclin-dependent kinases ensure proper cell cycle timing 1. yeast mutants identified cell-division cycle (CDC) genes 3
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lec35 - Lecture 35 Cell Cycle Control and Cancer Genetics...

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