9-13 1 PM Structure, classification & replication

9-13 1 PM Structure, classification & replication -...

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Virus structure, classification and replication
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Viruses defined Obligate intracellular parasites
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(From Medical Microbiology, 4 th ed., Murray, Rosenthal, Kobayashi & Pfaller, Mosby Inc., 2002, Fig. 65-1.) Under attack!
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From Medical Microbiology, 5 th ed., Murray, Rosenthal & Pfaller, Mosby Inc., 2005, Fig. 6-4. Structures compared
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Basic virus structure Capsid protein Nucleocapsid Naked capsid virus DNA RNA or = + Nucleocapsid Lipid membrane, glycoproteins Enveloped virus +
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Capsid symmetry Icosahedral Helical Naked capsid Enveloped Lipid Glycoprotein Matrix
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Icosahedral naked capsid viruses Adenovirus Electron micrograph Foot and mouth disease virus Crystallographic model http://www.ncbi.nlm.nih.gov/ICTVdb/Images/Ackerman/Animalvi/Adenovir/799-16.htm http://virology.wisc.edu/virusworld/ICTV8/fmd-foot-and-mouth-ictv8.jpg
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Helical naked capsid viruses Tobacco mosaic virus Electron micrograph Tobacco mosaic virus Model RNA Protein http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/em_tmv.gif Caspar and Klug, Adv Virus Res. 1960;7:225-325
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Icosahedral enveloped viruses Herpes simplex virus Electron micrograph Herpes simplex virus Nucleocapsid cryoEM model http://web.uct.ac.za/depts/mmi/stannard/emimages.html http://virology.wisc.edu/virusworld/images/herpescapsid.GIF
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Helical enveloped viruses Influneza A virus Electron micrograph Paramyxovirus Electron micrograph http://web.uct.ac.za/depts/mmi/stannard/fluvirus.html http://web.uct.ac.za/depts/mmi/stannard/paramyx.html
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Properties of enveloped viruses Envelope is sensitive to Drying Heat Detergents Acid Consequences Must stay wet during transmission Transmission in large droplets and secretions Cannot survive in the gastrointestinal tract Do not need to kill cells in order to spread May require both a humoral and a cellular immune response Adapted from Murray, P.R. Rosenthal K.S., Pfaller, M.A. (2005) Medical Microbiology, 5 th edition, Elsevier Mosby, Philadelphia, PA Box 6-5
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This note was uploaded on 07/02/2011 for the course MMC 6500 taught by Professor Gulig during the Spring '11 term at University of Florida.

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9-13 1 PM Structure, classification & replication -...

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