9-15 1 PM Papillomaviruses

9-15 1 PM - Papillomaviruses Relevance Warts Cancer Cervical cancer The most common HPVassociated cancer Almost all cervical cancer is caused by

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Papillomaviruses
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Relevance Warts Cancer Cervical cancer: The most common HPV- associated cancer. Almost all cervical cancer is caused by HPV. Vulvar cancer: About 40% are linked to HPV. Vaginal cancer: About 70% are linked to HPV. Penile cancer: About 40% are linked to HPV. Anal cancer : About 85% are linked to HPV. Head and neck cancer: 25% of mouth and 35% of throat cancers may be linked to HPV.
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History 1907: Warts can be transmitted with cell free filtrates 1933: Shope describes cottontail rabbit papilloma virus 1976: association of HPV with human cervical carcinoma 1980's: In vitro transformation assay; Bovine Papillomavirus (BPV-1) is prototype virus for study
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Classification Widespread in nature, infecting many vertebrates Highly species specific 100 + HPV types, classified basis on nucleic acid homology
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Human papillomavirus infections Transmission Direct contact with broken skin or mucosa Skin warts Genital tract HPV's Mucosal HPV's Various HPV types show tissue specificity
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HPV and skin warts (From Fields Virology, 4th ed, Knipe & Howley, eds, Lippincott Williams & Wilkins, 2001, Table 66-3.)
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From Medical Microbiology, 5 th Papillomavirus disease
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Clinical genital tract and mucosal HPV’s (From Fields Virology, 4th ed, Knipe & Howley, eds, Lippincott Williams & Wilkins, 2001, Table 66-4.)
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HPV virion Icosahedral, nonenveloped, 52-55 nm diameter Two capsid proteins, 55 kD and 70 kD, encoded by L1 and L2 genes
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HPV16 genome Genomic map of HPV-16. The genome is a double-stranded circular DNA molecule of 7904 base pairs. Transcription occurs in a clockwise manner; the only transcriptional promoter presently mapped for HPV-16 is designated P97. The open reading frames deduced from the DNA sequence are designed E1 to E7, L1, and L2 and are indicated outside of the circular genome. AE and AL represent the early and late polyadenylation sites. The viral long control region (LCR) contains transcriptional and replication regulatory elements. (From Small (8 kb) closed circular dsDNA, complexed with cellular histones in nucleosome structure. Small genome, genetic simplicity, implies strong host dependence, few targets for antivirals, stimulates host to assist in replication. Ten genes, 8 early (E) and 2 late (L)
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This note was uploaded on 07/02/2011 for the course MMC 6500 taught by Professor Gulig during the Spring '11 term at University of Florida.

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9-15 1 PM - Papillomaviruses Relevance Warts Cancer Cervical cancer The most common HPVassociated cancer Almost all cervical cancer is caused by

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